While CoQ10 is well known and extensively researched as a supplement, there are challenges with absorption and stability that may limit its ability to treat and prevent a wide variety of diseases and conditions. Fortunately, enhancing CoQ10 with gamma cyclodextrin can help assure dramatically better absorption, and by extension, better results. The addition of gamma cyclodextrin to CoQ10 is one of the most exciting developments for anyone dealing with cardiovascular diseases, cognitive health, or any serious illness.

Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model.

BHAGAVAN HN, CHOPRA RK, CRAFT NE, CHITCHUMROONCHOKCHAI C, FAILLA ML. ASSESSMENT OF COENZYME Q10 ABSORPTION USING AN IN VITRO DIGESTION-CACO-2 CELL MODEL. INT J PHARM. 2007 MAR 21;333(1-2):112-7.

BACKGROUND: The feasibility of using a coupled in vitro digestion-Caco-2 cell uptake as a model for examining the digestive stability and absorption of coenzyme Q10 (CoQ10) from a variety of commercially available CoQ10 products was examined.

METHODS: The products were first subjected to simulated digestion to mimic their passage through the GI tract to generate micelles containing CoQ10, and the micelle fractions added to monolayers of Caco-2 cells to determine CoQ10 uptake.

RESULTS: The data demonstrate enhanced uptake of CoQ10 from formulations containing solubilized forms of CoQ10 and also from a CoQ10-gamma-cyclodextrin complex as compared with pure CoQ10 powder or tablets based on CoQ10 powder. The CoQ10 uptake by the cells was correlated with the extent of micellarization of CoQ10 during simulated digestion. Most of CoQ10 taken up by the cells was converted to ubiquinol either during or following uptake. The data also indicate a correlation between in vitro dissolution of CoQ10 products and uptake of CoQ10 by Caco-2 cells.

CONCLUSION: Thus, this study demonstrates the utility of coupled in vitro digestion-Caco-2 cell model as a cost-effective screening tool that will provide useful information for the optimal design of human trials to assess the bioavailability of CoQ10 and also other bioactive compounds.

WHY COQ10?

While CoQ10 has shown remarkable results, getting a readily-absorbed form of the nutrient can help patients get reliable, positive outcomes for some of the most serious conditions.

• Prevents blocked arteries
• Prevents recurrence of heart failure
• Strengthens the heart muscle
• Controls blood pressure
• Reduces damage caused by statins
• Inhibits progression of Parkinson’s
• Relieves migraines
• Promotes healthy aging and exercise recovery
• Preserves cognitive health
• Stops dangerous oxidative damage

Why Enhanced Absorption CoQ10 with Gamma Cyclodextrin?

For Intensive Protection and Healing from Disease.

Coenzyme Q10, popularly known as CoQ10, is one of the most widely used supplemental nutrients in America. That’s because CoQ10 is a critical nutrient; it sparks the process of creating the fuel that powers the body at a microscopic level. The heart, brain, and every energy intensive aspect of the body and mind need a lot of CoQ10 to work at their best, so providing additional amounts to boost your CoQ10 levels has the potential to work wonders.

However, like all nutrients, CoQ10 needs to be absorbed in order to be effective. As this study shows, one of the most successful ways of enhancing absorption is by combining CoQ10 with gamma cyclodextrin—improving absorption by 8 times.

A plant-based oligosaccharide, gamma cyclodextrin surrounds hard-to-absorb and fat-soluble ingredients in an open-ended microscopic structure, the exterior of which is water-soluble, helping to escort the nutrients through the lining of the intestines and into the bloodstream.

One of the ways of testing the absorption and bioavailability of nutrients is with a scientific test known as Caco-2 study. Caco-2 cells are cultured human intestinal epithelial cells, that is, they are the same cells that line the intestines and absorb nutrients. This testing method is a gold standard in both the pharmaceutical and nutraceutical industries. It is an extremely efficient way to gauge just how well any given substance will absorb after it is consumed.

In this case, the researchers compared a CoQ10/ gamma cyclodextrin combination versus other common CoQ10 forms, including powder, capsule, chewable tablet, and softgel formulations.

After a controlled simulated gastric and intestinal digestion process, the researchers measured what would remain to be absorbed by the Caco-2 cells. The result was impressive: compared to all other supplement forms, and the plain CoQ10 powder, the CoQ10 combined with gamma cyclodextrin was 8 times better absorbed.

If your patients take cholesterol-lowering drugs called statins, have concerns about keeping your mind and heart working in peak condition, or just want to live life to the fullest, adding CoQ10 with gamma cyclodextrin to your daily regimen is a must. That small enhancement to this critical nutrient could make all the difference in your patients health. After all, better absorption means more effective CoQ10, and strong positive results for serious health concerns that are life-changing and lifesaving.