While grape seed extracts have been popular in the past, two issues have dampened the initial enthusiasm for grape seed: adulteration and lack of efficacy due to high tannin content that limits the absorption of oligomeric proanthocyanidins (OPCs). Fortunately, a tannin-free French grape seed extract can live up to the botanical’s potential.


Grape seed extract has the potential to be one of the most valuable natural medicines in the 21st century. Clinical and leading edge scientific research shows that it can reduce the risk of heart disease, stop the spread of cancer cells, speed the healing of damaged muscle tissue, reduce inflammation overall, and stop escalating blood sugar levels and weight gain.

But one of the problems of grape seed extracts is that their best attributes, oligomeric proanthocyanidins (OPCs) and other compounds aren’t absorbed because supplemental products are high in tannin content. Or, the grape seed extracts are so adulterated or don’t provide absorbable OPCs at all.

However, a tannin-free French grape seed extract, standardized to contain only low-molecular weight, abosorbable OPCs could change the way health practitioners and patients alike think about this botanical.

A French grape seed extract may:

  • Lower blood pressure
  • Stop deep vein thrombosis
  • Prevent diabetes and obesity
  • Speed muscle recovery
  • Inhibit tumor growth
  • Slow Alzheimer’s progression
  • Stop inflammation
  • Prevent oxidative damage

Protects the Cardiovascular System
Most people probably know grape seed extract because of its benefits for the heart. There’s good reason for this. Grape seed extract reduces high blood pressure, protects the blood vessel walls from damaging free radical activity, and prevents the dangerous oxidation of LDL cholesterol—one of the first steps on the road to a heart attack or stroke.

In an Italian clinical study, individuals with pre- or mild hypertension were divided into three groups, two with grape seed extract, at lower and higher dosages (150 mg and 300 mg per day, respectively), and one with a diet and exercise intervention only, serving as a control group. At the end of the four-month trial, both grape seed extract groups saw an improvement in blood pressure, although those at the higher dosage—300 mg daily—noticed more dramatic effects. In fact, blood pressure numbers normalized in 93 percent of those in the higher dosage group.

Research published in the Annals of the New York Academy of Sciences examined the vasodilating properties of grape seed fractions.

This study showed that grape seed proanthocyanidins promoted nitric oxide (NO) release and an increase in cyclic GMP levels. While nitric oxide is a molecule that is only active for a few seconds at a time in the bloodstream, it is a desired target for many natural compounds, especially in treating hypertension. It has beneficial effects for blood pressure, helping signal the opening of blood vessels and arteries. Cyclic GMP (cGMP) also relaxes smooth muscles, including blood vessels.

Another clinical study, published in the Journal of Medicinal Food compared the results of individuals with mildly high cholesterol taking a grape seed extract versus a placebo for 8 weeks.  Lipid profiles and oxidized LDL (bad) cholesterol were improved in those taking grape seed extract. The researchers concluded that grape seed extract decreased the risk of blood clotting (without adverse effects on blood thinning) and other cardiovascular disorders.

Other scientific studies have found similar results: grape seed extract helps prevent blood clots from forming, lowers blood pressure, and shields blood vessels and arteries from free radical damage. There may be no more powerful natural medicine to protect against heart disease than French grape seed extract.

Stops Diabetes and Obesity
While the most important things a person can do to manage weight and prevent diabetes is to follow a healthy eating and sensible exercise plan, there is no denying that grape seed extract can be a key part in getting healthy and recovering from sugar addiction. For example, a clinical study in Thailand found that grape seed extract reduced blood sugar levels after a high-carbohydrate meal. The OPCs in grape seed can help stop the sugar spikes that affect insulin levels and possibly lead to diabetes.

Another study in 2009 found that grape seed extract reduced both buildup of abdominal fat and blood sugar levels.  This was due, in part, to an increase of adiponectin, a protein responsible for regulating blood sugar, insulin metabolism, cholesterol, and inhibiting NF-kB activation and other inflammatory markers. Compared to the control group, the adiponectin level of the grape seed group increased 61 percent.  Other scientific studies have found similar results—grape seed extract activates cyclic AMP, protects against fat accumulation, and improves blood triglyceride and plasma lipid levels.

Speeds Recovery from Exercise and Injury
The anti-inflammatory power of grape seed extract has brought it to the attention of researchers studying its effects on muscle recovery. In these investigations, grape seed OPCs have boosted anti-inflammatory cytokines (IL-10), and helped regenerate damaged muscle fibers. Macrophages, known for their ability to stop bacteria and viruses, also help heal injured tissue.  One study found that elevated levels of macrophages and neutrophils (white blood cells found at the scenes of inflammation) were completely resolved in just 5 days when using grape seed extract.

Prevents Cancer and Tumor Growth
Colorectal cancer has the second highest mortality rate in the United States. While lifestyle and diet can prevent or modify the risk, there is an urgent need for effective therapies that don’t come with a host of serious adverse effects.

Cancer develops through many mechanisms, and that’s why it is so difficult to treat. However, a breakthrough study found that a tannin-free French grape seed extract (VX1) was found to suppress colorectal cancer cells in a variety of ways.

It inhibits the growth of tumors, stops the cycle of cancer cell signaling, and induces apoptosis—the death of cancer cells by stopping the growth phase. But perhaps even more importantly, it also kills cancer stem cells.

This is an amazing breakthrough because even though conventional chemotherapy can kill cancer cells, it doesn’t finish off cancer stem cells-—the very reason cancer can recur and spread throughout the body. The OPCs from this grape seed extract eliminated the cancer stem cells. And it could be easily used as an adjunct therapy.

Additional research on this same French grape seed has found that being standardized for tannin-free OPCs truly does make a difference. Compared to a grape seed extract that was not standardized for these crucial components, (unfractionated) it reduced tumor size by 65 percent versus 13 percent for the common grape seed extract in an in vivo study.

This French grape seed (VX1) has also been shown to work well with curcumin combined with turmeric essential oil, a source of ar-turmerone. The researchers determined that scaled up for human use, even small dosage levels of the grape seed extract—from 240 mg to 600 mg daily—would be effective.

Other research has examined the effect of grape seed extract on breast cancer cells when used alone or with a conventional treatment. The results showed that the two interventions worked well together, but that grape seed extract alone was a strong inhibitor of breast cancer cells. These results have been mirrored in other research showing that grape seed extract polyphenols have a strong ability to stop tumor growth.

One of the reasons for this is that grape seed extract inhibits aromatase, an enzyme that converts androgen into estrogen. Certain types of cancer grow and spread in the presence of estrogen. Breast and prostate cancer tissues typically have higher levels of aromatase. A study published in the journal Cancer Research discussed the valuable potential of grape seed extract, when their research showed that it inhibited aromatase activity and reduced growth in MCF-7 breast cancer cells. They concluded, “We believe that these results are exciting in that they show grape seed extract to be potentially useful in the prevention/treatment of hormone-dependent breast cancer through the inhibition of aromatase activity as well as its expression.”

Aside from helping inhibit tumor cells, grape seed has other applications for cancer treatment. An Australian scientific study found that grape seed extract reduced the severity of mucositis, the painful inflammation of the mucous membranes of the digestive tract, including the mouth and small intestines due to chemotherapy. The researchers also found that grape seed extract killed colon cancer cells outright. Other grape seed studies have shown that it stops prostate cancer cells through direct stimulation of tumor suppressing cells, and bladder cancer by increasing oxidative stresses only to cancer cells, halting their growth, while leaving healthy cells alone.

An additional way grape seed extract stops cancer is by preventing cancer cells from connecting to blood vessels, and depriving them of oxygen and nutrients.

For patients who spend a lot of time outdoors and skin cancer is a concern, grape seed extract may offer protection here as well: a Romanian study reported that keratinocytes (the major type of cells in the outer layer of the skin) treated with grape seed extract 30 minutes before UVB radiation were protected from damage.

Slows Alzheimer’s Progression and Promotes Cognitive Health and Focus
Because of their antioxidant and anti-inflammatory activity, grape seed OPCs are increasingly on the cutting edge of Alzheimer’s research.  Studies have shown that they protect the delicate circuitry of the brain. For example, an Indian study found that grape seed proanthocyanidins reduce the effects of oxidative stress in the aging brain and consider it a neuroprotectant to prevent cognitive loss. The nutrient’s ability was due, in part, to its blood glucose lowering as much as its free-radical fighting power.  Considering the growing body of research that points to a connection between blood sugar levels and risk of Alzheimer’s, this is an important discovery. Other work has examined more direct effects of grape seed extract on Alzheimer’s disease (AD).

Studies conducted by the Mount Sinai School of Medicine showed that grape seed extract inhibited the formation of plaques and tangles, and aside from preventing the buildup or clustering of beta-amyloid, grape seed extract supported greater brain plasticity and creation of new neural pathways.

Other OPC research has investigated the application of this natural ingredient to attention deficit/hyperactivity disorder (ADHD) in children. A placebo-controlled, double-blind study published in the journal European Child & Adolescent Psychology found that after just one month, OPCs boosted attention span, caused a significant reduction of hyperactivity, and improved motor coordination.  The researchers noted that the symptoms returned one month after stopping the treatment, so OPCs would need to be part of an ongoing regimen.

Stops Inflammation and Oxidative Damage
Grape seed extract OPCs fight inflammation and the effects of free radicals throughout the body. While we often associate antioxidant power with anti-aging, it also controls the immune system to reduce everything from damaging chronic joint inflammation in rheumatoid arthritis (RA) to allergic responses.

A Saudi Arabian study found that grape seed OPCs were able to regulate the activity of certain immune-regulating T-cells, inducing some and reducing others, in a way that stopped inflammatory markers. The researchers concluded that grape seed extract proanthocyanidins could become an adjunct therapy for RA, or possibly an alternative treatment in its own right.

Because autoimmune inflammation also interferes with the process of bone formation and resorption, individuals with RA often contend with structural joint damage. However, researchers in Korea discovered the ability of grape seed OPCs to reduce inflammation also stopped the symptoms of collagen-induced arthritis in a laboratory study. It actually helped get the natural process of building bone back on track.

Aside from combating RA symptoms and bone damage, grape seed extract prevents the inflammation that causes allergy-induced asthma symptoms. A Korean study found that grape seed extract reduced the allergic hyper-responsiveness that restricts bronchial airways, as well as the amount of inflammatory markers in lung tissue. The researchers felt that grape seed extract could be a valuable therapeutic ingredient for acute and chronic asthma. Considering French OPC grape seed extract is free of side effects and risks, this could be excellent news for those who are looking for an addition to their asthma treatment.

Other Powerful Benefits of Grape Seed Extract
A double-blind, placebo-controlled clinical study published in the journal Menopause, grape seed improved a multitude of health factors for women in menopause. The study was divided into a low- and high-dose grape seed group and one placebo group. Both grape seed groups saw a reduction in anxiety, blood pressure levels, and an increase in lean muscle mass. Specific menopause symptoms, including hot flashes and insomnia, improved in the high-dose group.

In other work, researchers in Austria have found that OPCs from grape seed are effective antibacterial agents against ten different pathogens. A study reported in the Journal of Toxicological Sciences measured the abilities of grape seed extract against methicillin-resistant Staphylococcus aureus (MRSA), a staph bacteria that is difficult to treat because it has developed to become resistant to antibiotics. The researchers found that grape seed extract was effective against 43 strains of the bacteria, and could, in the words of those conducting the study, “signify a major advancement in the treatment of MRSA diseases.”

Grape seed extract also shows promise for people suffering from non-alcoholic fatty liver disease (NAFLD), a form of hepatic steatosis where the fats are deposited in the liver. The causes can vary—some people are just genetically prone to the disease, while other research points to dietary reasons, including the overconsumption of soft drinks. In fact, 70 percent of the cases of NAFLD are associated with metabolic syndrome.

Clinical research in Iran compared the liver restorative power of grape seed extract to vitamin C, which served as a control group medication. While everyone is familiar with vitamin C—and I think it’s a valuable nutrient—fighting NAFLD requires a stronger intervention. One of the ways of measuring liver damage is by taking note of the levels of an enzyme called alanine aminotransferase. When the liver is functioning properly, levels are low. When it is diseased, they can rise dramatically. In this clinical study, individuals in the grape seed extract group saw significant changes in just three months. Grape seed extract reduced the accumulation of fat deposits in the liver, stopped oxidative damage, and lowered levels of alanine aminotransferase levels in the blood.

The antioxidant power of grape seed extract may one day help those undergoing radiation treatment. Because the liver reacts so poorly to radiation treatment (regardless of whether the liver or another part of the body is a target of the therapy), it suffers damage that becomes a serious secondary concern. Turkish scientific research showed that grape seed extract protected liver cellular membranes from oxidative damage, and from protein and lipid oxidation. Their work showed that grape seed actually restored levels of antioxidant parameters after radiation treatment. While this is cutting-edge work, and more studies need to be done, it’s exciting to think that grape seed extract could have this kind of powerful result.

Not All Grape Seed is Effective
While there have been astounding results from grape seed studies, a supplemental source needs to be carefully selected.

In order to be effective, the OPCs—the primary disease-fighting compounds from grape seed—need to be absorbed. Unfortunately, many extracts are mostly very large molecular weight tannins, which can’t be absorbed, even though they are still technically OPCs. However, supplement labels sometimes count all OPCs as being the same, whether they are very small and effective, or large and unabsorbable and ineffective. And some products labeled as “grape seed extract” don’t actually contain any at all. In fact, it is one of the most adulterated supplements on the market.

That’s why a tannin-free French grape seed extract that is standardized to provide only OPCs that are small enough to guarantee absorption, with a high level of polyphenols is best. It can help your patients experience the full potential of grape seed extract and its astounding array of benefits for overall health and vitality.

Recommend taking 150-1,200 mg of tannin-free French grape seed extract daily.

For more information on this topic, watch this video: Heart Disease, High Blood Pressure, Cancer, Diabetes, Arthritis, and More – Grape Seed Extract